About Jotbody

A proven track record

Jotbody is a biotechnology company founded in 2020 by a group of globally recognized scientists and senior executives with well-documented experience in biotherapeutics development and entrepreneurship. Jotbody is on the cutting edge for the discovery and engineering of nanobodies from camelids and sharks and has completed numerous custom discovery projects for industry and academic institutions with a success rate of 100%. Our cutting-edge technology and global dual sites enable us to deliver innovative solutions to clients in industry and academia. Our growing list of satisfied clients and partners reflects our commitment to scientific excellence, innovation, and customer satisfaction. Whether you need assistance with a specific project or are interested in exploring the potential of nanobodies, we invite you to contact us to learn more about Jotbody.

“It is truly a five-star experience regarding order handling, technical support, and product quality. After trying other vendors for nanobody generation, Jotbody is the one I will definitely recommend to my colleagues” – Bill Wong | VP Preclinical Development, InnoRNA

“I am writing to express my sincere appreciation for the quality of antibody service you provided. I really appreciate your efficient, gracious service, the level of detail, professionalism, and accountability you have demonstrated on my project, and the way you conduct business as a whole.” – Hua Zhang | VP and Chief Scientific Officer, SPH Biotherapeutics

“We achieved successful cell targeting using your nanobody-clicked EVs. Thanks for your continuous support – it has been great working with you”Anna Cifuentes-Rius | Director Research & Innovation, Exopharm

Our offerings

Products and services

slide-img
Nanobody reagents

High-performance VHH and vNAR antibodies for specialized applications

Learn more
slide-img
Antibodies

Discover and study disease mechanisms with our high-quality antibodies for research purposes

Learn more
slide-img
ELISA kits

Achieve accurate and reliable results in detecting and quantifying proteins with our ELISA kits

Learn more
slide-img
Recombinant proteins

Discover recombinant proteins for research and unleash their potential to advance scientific knowledge

Learn more
slide-img
Biological materials

Explore our premium biological materials, meticulously sourced to meet strict quality and ethical standards

Learn more
slide-img
Discovery services

Our experience combined with proprietary technologies provides an excellent choice for nanobody discovery and production

Learn more
slide-img
Nanobody engineering

Rapidly reformat your nanobody into any format for research, diagnostic, and therapeutic use

Learn more
slide-img
Sequencing

Expand your nanobodies’ potential with our sequencing service, which is the starting point for embarking on engineering projects

Learn more
slide-img
Large-scale protein production

Jotbody provides comprehensive protein expression and services tailored to meet every client’s requirement

Learn more
slide-img
ELISA kits development

Develop your own sensitive and specific ELISA together with our experienced partners

Learn more
slide-img
Antibody validation

Achieve reproducible and reliable results by validating each antibody for your specific application

Learn more
slide-img
Exosome omics

Accelerate your discoveries and gain a deeper understanding of exosome biology and their role in disease progression

Learn more

Our exclusive shark platform

Decades have passed since the discovery of the peculiar heavy-chain antibodies in camelids (VHH), followed by the elucidation of the similar, heavy-chain-only structure of sharks' new antigen receptors (vNAR). Both of them share several characteristics such as high stability and solubility, longer than average CDR3 loops, and the presence of non-canonical disulfide linkages sculpting the binding site.

While VHH domains have attracted great interest as biological drugs and proven to be successful in clinical trials, the engineering of vNAR domains for biomedical applications is at an early stage. Despite this, it is abundantly clear that they present a singular molecular framework that can be exploited to develop reagents for scientific research, disease diagnosis, and/or therapeutic intervention.

Camelids VHH vs Sharks vNAR
Alpacas-e1688359819361.jpg

Discovery services

Jotbody provides discovery services for nanobodies from immunized and naive libraries. We source the best alpaca livestock in Australia for our immunization program, generating diverse immune responses and high-quality antibodies. Our experienced scientists work closely with clients to deliver tailored solutions and successful outcomes.

Knowledge centre

Why nanobodies?

Nanobody, also called single-domain antibody, is the variable region isolated from the antigen-binding variable domain (VHH) of camelid heavy chain-only antibody or the variable domain (vNAR) of cartilaginous fish immunoglobulin new antigen receptor (IgNAR). With a size of just 12~15 kDa (2~4 nm), nanobody is the smallest antigen-binding fragment discovered today and holds a plethora of intrinsic advantages over conventional monoclonal antibodies.

Naïve Library 2

Immunized vs naïve libraries

Antibody libraries can be generated from immune hosts who have developed a strong and specific humoral response against the desired target or naïve hosts who have never been challenged with a specific immunogen. Whether you need a partner to develop high-diversity immune libraries for antibody phage display or ready-made naïve antibody libraries, Jotbody offers them all to suit your needs.

News and events

Stay informed with our latest product releases,
promotions, technical content, and upcoming events