Innovation and technology


  • High-affinity anti-EGFP and anti-SARS-CoV-2 vNAR single domain antibodies and use thereof. PCT/CN2021/128297
  • Method of Producing Antibody Fragment. CN201811318557.4
  • Specific primer pairs designed for single variable new antigen receptor domain derived from IgNAR of Chiloscyllium plagiosum. CN111197074A
  • Method of Producing Antibody Fragment. US20190135904

Selected publications:

  • Bamboo sharks for affordable single domain antibody production. Front. Bioeng. Biotechnol. 9:792111
  • Cas9-based local enrichment and genomics sequence revision of megabase-size shark immunoglobulin new antigen receptor loci. J Immunol. 2022 Jan 1;208(1):181-189
  • Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery. J ExtracellVesicles. 2021;10:e12057
  • The White-Spotted Bamboo Shark Genome Reveals Chromosome Rearrangements and Fast-Evolving Immune Genes of Cartilaginous Fish. Iscience. 2020; 23(11): 101754
  • The novel llama-human chimeric antibody has potent effect in lowering LDL-c levels in hPCSK9 transgenic rats. Clin Trans Med. 2020;09, 16