Knowledge centre

Jotbody is engaged in the discovery of nanobody-based products from both camelids and sharks using both immunized and naïve libraries. Learn more about the superior properties of nanobodies, how they differ between camelids and sharks, and the differences between our nanobody immunized and naïve library services.

Why nanobodies?

Nanobody, also called single-domain antibody, is the variable region isolated from the antigen-binding variable domain (VHH) of camelid heavy chain-only antibody or the variable domain (vNAR) of cartilaginous fish immunoglobulin new antigen receptor (IgNAR). With a size of just 12-15 kDa (2~4 nm), nanobody is the smallest antigen-binding fragment discovered today and holds a plethora of intrinsic advantages over conventional monoclonal antibodies.

Naïve Library 2

Immunized vs naïve

Antibody libraries can be generated from immune hosts who have developed a strong and specific humoral response against the desired target or naïve hosts who have never been challenged with a specific immunogen. Whether you need a partner to develop high-diversity immune libraries for antibody phage display or ready-made naïve antibody libraries, Jotbody offers them all to suit your needs.