Discovery services

At Jotbody, we are dedicated to the discovery of nanobodies. Our platform offers two distinct approaches to generating nanobodies: immunized and naïve libraries.
Here’s how each approach works:
Immunized Library Approach
Our immunized library approach involves generating a nanobody library from camelids or sharks that have been immunized with the target antigen. This approach is particularly useful when the antigen is well characterized and when a strong immune response is expected. With our immunization program in Australia, we optimize the protocol to ensure a robust and specific immune response. We then use high-throughput screening methods to identify nanobodies with the desired binding properties.
Naïve Library Approach
Our naïve library approach utilizes a diverse collection of nanobodies generated from an animal without prior exposure to the antigen of interest. This approach is particularly useful when the antigen is not well characterized or when the target is difficult to generate antibodies against. We use state-of-the-art screening techniques to identify nanobodies with high affinity and specificity toward the target antigen.
Our team of experts has extensive experience in immunized and naïve library approaches, and we work closely with our clients to determine which approach best suits their specific needs. We also offer customized solutions to meet the unique requirements of each project, including antibody engineering and optimization, as well as downstream applications such as imaging, diagnostics, and therapeutics.
Whether you are looking to generate nanobodies using immunized or naïve libraries or require customized solutions for your specific project, our team is here to help.
Contact us today to learn more about our services and how we can assist you in your research endeavors.

Our nanobody immunized library approach leverages the strong immune response of animals to generate a diverse library of high-affinity nanobodies against a specific antigen of interest.

With our single-domain antibody naïve library approach, we can rapidly and efficiently generate a diverse collection of nanobodies from an animal that has not been exposed to the target antigen, enabling the identification of unique and highly specific binders.